Methoxybenzoic acids and derivatives
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eMolecules 16695-14-0 | 3-Methoxy-3-oxopropanoic acid | ChemScene | MFCD00667796 | 118.088 | C4H6O4 | 95.000 | COC(=O)CC(O)=O | 25g | 569147812
3-Methoxy-3-oxopropanoic acid | ChemScene | 16695-14-0 | MFCD00667796 | 118.088 | C4H6O4 | 95.000 | COC(=O)CC(O)=O | 25g | 569147812
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Medchemexpress LLC Ro 08-2750 | 37854-59-4 | 98.01% | 270.24 | 10 MG
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 μM. It selectively inhibits NGF binding to p75NTR over TRKA. Ro 08-2750 is also a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.
- Binds to the NGF dimer, potentially inducing a conformational change that prevents NGF from binding to p75NTR.
- Completely rescues cells from NGF-induced SK-N-MC 103 cell death at 10 nM.
- Increases differentiation and apoptosis in myeloid leukemia cells at 5-10 μM (8 hours).
- Inhibits survival of human AML lines and patient cells.
- Inhibits MSI2 RNA-binding and alters MSI2 gene signature.
- Inhibits leukemogenesis in a myeloid leukemia model in vivo at 13.75 mg/kg (i.p.).
- Reduces c-MYC levels and disease burden in a myeloid leukemia model.
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